two HTTPS applications on the same host

Sorry, if there is some similar question.I'm interesting if it possible to run to HTTPS applications on the same host machine, for example:

1. Python FastAPI Back-End on port **8000 ** that use HTTPS
2. JS React Front-End on port **4000 ** that also use HTTPS

It will work fine without any tricks like TLS Proxy? or so on?

I have read that one host can have only one certificate what is mean only one application can have HTTPS, but beside that I read that it is possible to do it without any Proxy, nginx and so...

I would be so thankful if someone could explain me that part, or give some links for resources